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TET2 抗体

TET2 适用: 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7270780
发货至: 中国
  • 抗原 See all TET2 抗体
    TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))
    适用
    • 48
    • 14
    • 6
    小鼠
    宿主
    • 41
    • 8
    • 2
    克隆类型
    • 43
    • 8
    多克隆
    标记
    • 33
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TET2 antibody is un-conjugated
    应用范围
    • 39
    • 23
    • 11
    • 7
    • 7
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    原理
    TET2 Rabbit pAb
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein of mouse TET2.
    亚型
    IgG
    Top Product
    Discover our top product TET2 Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))
    别名
    TET2 (TET2 产品)
    别名
    KIAA1546 antibody, MDS antibody, Ayu17-449 antibody, E130014J05Rik antibody, mKIAA1546 antibody, RGD1311625 antibody, tet methylcytosine dioxygenase 2 antibody, TET2 antibody, Tet2 antibody
    背景
    Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC into 5-hydroxymethylcytosine (5hmC and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC, and conversion of 5fC to 5-carboxylcytosine (5caC. Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.,Ayu17-44, Ayu17-449, mKIAA1546, E130014J05Rik,TET2
    分子量
    212kDa
    基因ID
    214133
    UniProt
    Q4JK59
    途径
    Warburg Effect
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