The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],MST091,MST122,MST127,MSTP091,MSTP122,MSTP127,MXRA6,PPP1R155,TNS,TNS1,Epigenetics & Nuclear Signaling,RNA Binding,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,Extracellular Matrix,Neuroscience,Calcium Signaling,TNS1