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SMAD4 抗体

KO Validated SMAD4 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated
产品编号 ABIN7270340
发货至: 中国
  • 抗原 See all SMAD4 抗体
    SMAD4 (SMAD Family Member 4 (SMAD4))
    适用
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    宿主
    • 84
    • 11
    • 1
    克隆类型
    • 73
    • 23
    单克隆
    标记
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    This SMAD4 antibody is un-conjugated
    应用范围
    • 64
    • 45
    • 37
    • 28
    • 21
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
    原理
    [KO Validated] Smad4 Rabbit mAb
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Monoclonal Antibodies
    纯化方法
    Affinity purification
    质量等级
    KO Validated
    免疫原
    Recombinant protein of human Smad4.
    亚型
    IgG
    Top Product
    Discover our top product SMAD4 Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    SMAD4 (SMAD Family Member 4 (SMAD4))
    别名
    SMAD4 (SMAD4 产品)
    别名
    smad4 antibody, DPC4 antibody, JIP antibody, MADH4 antibody, MYHRS antibody, AW743858 antibody, D18Wsu70e antibody, Madh4 antibody, XSmad4alpha antibody, Xsmad4 antibody, dpc4 antibody, jip antibody, madh4 antibody, xsmad4a antibody, SMAD family member 4 antibody, Smad4 protein antibody, SMAD family member 4, gene 1 L homeolog antibody, SMAD4 antibody, smad4 antibody, Smad4 antibody, smad4.1.L antibody
    背景
    This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009],DPC4,JIP,MADH4,MYHRS,Smad4,SMAD4,Apoptosis,Cancer,Cardiovascular,Cell Biology & Developmental Biology,Cell Cycle,Endocrine & Metabolism,Epigenetics & Nuclear Signaling,ESC Pluripotency and Differentiation,G1/S Checkpoint,Heart,Heart_Cardiogenesis,Heart_Hypertrophy,Hypoxia,MAPK-JNK Signaling Pathway,Signal Transduction,Stem Cells,TGF-b-Smad Signaling Pathway,TGF-b-Smad Signaling Pathway_SMADs,Transcription Factors,Tumor suppressors,SMAD4
    分子量
    65kDa
    基因ID
    4089
    UniProt
    Q13485
    途径
    Cell Division Cycle, Chromatin Binding, Autophagy
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