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- 抗原 See all SLFN11 products
- SLFN11 (Schlafen Family Member 11 (SLFN11))
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适用
- 人
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This SLFN11 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 原理
- SLFN11 Rabbit mAb
- 交叉反应
- 人
- 产品特性
- Monoclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of human SLFN11.
- 亚型
- IgG
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anti-Schlafen Family Member 11 (SLFN11) (AA 670-821) antibody
SLFN11 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB,1:500 - 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- SLFN11 (Schlafen Family Member 11 (SLFN11))
- 别名
- SLFN11 (SLFN11 产品)
- 别名
- SLFN8/9 antibody, schlafen family member 11 antibody, SLFN11 antibody, LOC100071612 antibody
- 背景
- Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death. Acts independently of ATR. Also acts as an interferon (IFN-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1 by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA.,SLFN8/9,SLFN11
- 分子量
- 102kDa
- 基因ID
- 91607
- UniProt
- Q7Z7L1
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