SARS-Coronavirus Nonstructural Protein 13 (SARS-CoV NSP13) 抗体
SARS-CoV NSP13
适用: SARS Coronavirus-2 (SARS-CoV-2)
IF, WB
宿主: 兔
Polyclonal
unconjugated
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- 抗原
- SARS-Coronavirus Nonstructural Protein 13 (SARS-CoV NSP13)
- 适用
- SARS Coronavirus-2 (SARS-CoV-2)
- 宿主
- 兔
- 克隆类型
- 多克隆
- 应用范围
- Immunofluorescence (IF), Western Blotting (WB)
- 原理
- SARS-CoV-2 NSP13 Rabbit pAb
- 交叉反应
- SARS Coronavirus-2 (SARS-CoV-2)
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein of SARS-CoV-2 NSP13.
- 亚型
- IgG
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- 应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:200
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- SARS-Coronavirus Nonstructural Protein 13 (SARS-CoV NSP13)
- 别名
- NSP13
- 别名
- pp1a antibody, pp1ab antibody, orf1ab polyprotein (pp1ab) antibody, orf1ab antibody
- 物质类
- Viral Protein
- 背景
- [Spike protein S1]: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. Binding to host NRP1 and NRP2 via C-terminal polybasic sequence enhances virion entry into host cell. This interaction may explain virus tropism of human olfactory epithelium cells, which express high level of NRP1 and NRP2 but low level of ACE2. The stalk domain of S contains three hinges, giving the head unexpected orientational freedom. Uses human TMPRSS2 for priming in human lung cells which is an essential step for viral entry. Can be alternatively processed by host furin. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.,NSP13
- 基因ID
- 43740578
- UniProt
- P0DTD1
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