zgc:73070 antibody, xrnf185 antibody, 1700022N24Rik antibody, AL033296 antibody, ring finger protein 185 antibody, ring finger protein 185 L homeolog antibody, rnf185 antibody, rnf185.L antibody, RNF185 antibody, Rnf185 antibody
背景
E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER-associated degradation (ERAD pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.,RNF185,Cell Biology & Developmental Biology,RNF185