SNAX1 antibody, 6720407G21Rik antibody, AI481227 antibody, ring finger protein 170 antibody, ring finger protein 170 L homeolog antibody, microRNA 4469 antibody, Rnf170 antibody, RNF170 antibody, rnf170.L antibody, MIR4469 antibody
背景
This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene.,RNF170,ADSA,SNAX1,Rnf170,Cell Biology & Developmental Biology,Rnf170