The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011],RNF14,ARA54,HFB30,HRIHFB2038,TRIAD2,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Nuclear hormone receptors,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,RNF14