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PPP3CA 抗体

PPP3CA 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
产品编号 ABIN7269692
发货至: 中国
  • 抗原 See all PPP3CA 抗体
    PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
    适用
    • 50
    • 24
    • 21
    • 14
    • 10
    • 7
    • 7
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 37
    • 12
    • 2
    克隆类型
    • 36
    • 15
    单克隆
    标记
    • 44
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PPP3CA antibody is un-conjugated
    应用范围
    • 45
    • 15
    • 15
    • 12
    • 10
    • 8
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    原理
    Calcineurin A Rabbit mAb
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Monoclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    A synthesized peptide derived from human Calcineurin A
    亚型
    IgG
    Top Product
    Discover our top product PPP3CA Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
    别名
    PPP3CA (PPP3CA 产品)
    背景
    Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+ levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+ levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylates heat shock protein HSPB1 (By similarity. Dephosphorylates and activates transcription factor NFATC1. In response to increased Ca(2+ levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins. Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation.,CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B,B Cell Receptor Signaling Pathway,Calcium Signaling,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Actins,ErbB-HER Signaling Pathway,Immunology & Inflammation,Neurodegenerative Diseases,Neuroscience,Signal Transduction,T Cell Receptor Signaling Pathway,PPP3CA
    分子量
    59kDa
    基因ID
    5530
    UniProt
    Q08209
    途径
    RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Synaptic Membrane, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
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