Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate, different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity.,VPS34, Vps34, hVps34,AMPK Signaling Pathway,Angiogenesis,Apoptosis,Apoptosis_Inhibition of Apoptosis,Apoptosis_Mitochondrial Control of Apoptosis,Autophagy,Autophagy_Regulator,Cardiovascular,Cell Adhesion,Cell Biology & Developmental Biology,Cell Intrinsic Innate Immunity Signaling Pathway,Cytoskeleton,Cytoskeleton_Actins,Cytoskeleton_Microtubules,Endocrine & Metabolism,Epigenetics & Nuclear Signaling,ErbB-HER Signaling Pathway,ESC Pluripotency and Differentiation,IL-6 Receptor Signaling Pathway,Immunology & Inflammation,Innate Immunity_TLR Signaling,Kinase,Lipid Metabolism,MAPK-Erk Signaling Pathway,MAPK-JNK Signaling Pathway,mTOR Signaling Pathway,NF-kB Signaling Pathway,PI3K-Akt Signaling Pathway,PI3K-Akt Signaling Pathway_PI3Ks and related,Signal Transduction,T Cell Receptor Signaling Pathway,TGF-b-Smad Signaling Pathway,Toll-like Receptor Signaling Pathway,Translation Control,Translational Control_Regulation of eIF4 and p70 S6 Kinase,Warburg Effect,PIK3C3