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- 抗原 See all PAPD5 抗体
- PAPD5 (PAP Associated Domain Containing 5 (PAPD5))
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抗原表位
- AA 480-590
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PAPD5 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 原理
- PAPD5 Rabbit pAb
- 序列
- YYPNNETESI LGRIIRVTDE VATYRDWISK QWGLKNRPEP SCNGNGVTLI VDTQQLDKCN NNLSEENEAL GKCRSKTSES LSKHSSNSSS GPVSSSSATQ SSSSDVDSDA T
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 480-590 of human PAPD5 (NP_001035374.2).
- 亚型
- IgG
- Top Product
- Discover our top product PAPD5 Primary Antibody
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anti-PAP Associated Domain Containing 5 (PAPD5) (AA 497-510) antibody
Verified PAPD5 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-PAP Associated Domain Containing 5 (PAPD5) (AA 78-90) antibodyVerified PAPD5 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- WB,1:500 - 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- PAPD5 (PAP Associated Domain Containing 5 (PAPD5))
- 别名
- PAPD5 (PAPD5 产品)
- 别名
- TRF4-2 antibody, LOC568678 antibody, 5730445M16Rik antibody, 5830428A09 antibody, poly(A) RNA polymerase D5, non-canonical antibody, PAP associated domain containing 5 antibody, PAP associated domain containing 5 L homeolog antibody, PAPD5 antibody, Papd5 antibody, papd5 antibody, CC1G_07969 antibody, papd5.L antibody
- 背景
- Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A tail creating a heterogeneous 3' poly(A tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro. Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1. Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation. Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation.,PAPD5,TRF4-2,Epigenetics & Nuclear Signaling,RNA Binding,Cancer,Drug resistance,Topoisomerases,PAPD5
- 分子量
- 41kDa/51kDa/63kDa/64kDa/75kDa
- 基因ID
- 64282
- UniProt
- Q8NDF8
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