PAPD5 抗体 (AA 480-590)
Quick Overview for PAPD5 抗体 (AA 480-590) (ABIN7269170)
抗原
See all PAPD5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 480-590
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原理
- PAPD5 Rabbit pAb
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序列
- YYPNNETESI LGRIIRVTDE VATYRDWISK QWGLKNRPEP SCNGNGVTLI VDTQQLDKCN NNLSEENEAL GKCRSKTSES LSKHSSNSSS GPVSSSSATQ SSSSDVDSDA T
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 480-590 of human PAPD5 (NP_001035374.2).
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亚型
- IgG
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anti-PAP Associated Domain Containing 5 (PAPD5) (AA 78-90) antibody
Verified PAPD5 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-PAP Associated Domain Containing 5 (PAPD5) (AA 497-510) antibodyVerified PAPD5 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- PAPD5 (PAP Associated Domain Containing 5 (PAPD5))
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别名
- PAPD5
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背景
- Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A tail creating a heterogeneous 3' poly(A tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro. Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1. Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation. Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation.,PAPD5,TRF4-2,Epigenetics & Nuclear Signaling,RNA Binding,Cancer,Drug resistance,Topoisomerases,PAPD5
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分子量
- 41kDa/51kDa/63kDa/64kDa/75kDa
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基因ID
- 64282
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UniProt
- Q8NDF8
抗原
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