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Nicastrin 抗体 (AA 429-669)

NCSTN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7268905
发货至: 中国
  • 抗原 See all Nicastrin (NCSTN) 抗体
    Nicastrin (NCSTN)
    抗原表位
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 429-669
    适用
    • 35
    • 32
    • 21
    • 5
    • 5
    • 4
    • 1
    • 1
    宿主
    • 49
    • 2
    克隆类型
    • 42
    • 9
    多克隆
    标记
    • 19
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Nicastrin antibody is un-conjugated
    应用范围
    • 37
    • 13
    • 13
    • 9
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    原理
    NCSTN Rabbit pAb
    序列
    RFLRARNISG VVLADHSGAF HNKYYQSIYD TAENINVSYP EWLSPEEDLN FVTDTAKALA DVATVLGRAL YELAGGTNFS DTVQADPQTV TRLLYGFLIK ANNSWFQSIL RQDLRSYLGD GPLQHYIAVS SPTNTTYVVQ YALANLTGTV VNLTREQCQD PSKVPSENKD LYEYSWVQGP LHSNETDRLP RCVRSTARLA RALSPAFELS QWSSTEYSTW TESRWKDIRA RIFLIASKEL E
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 429-669 of human NCSTN (NP_056146.1).
    亚型
    IgG
    Top Product
    Discover our top product NCSTN Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    Nicastrin (NCSTN)
    别名
    NCSTN (NCSTN 产品)
    别名
    CG7012 antibody, Dmel\\CG7012 antibody, Nct antibody, Nic antibody, S5A antibody, ST96B antibody, agro antibody, dNct antibody, nic antibody, NCSTN antibody, DKFZp469O2418 antibody, APH2 antibody, 9430068N19Rik antibody, AA727311 antibody, Aph2 antibody, D1Dau13e antibody, Kiaa0253 antibody, mKIAA0253 antibody, nicastrin antibody, Nicastrin antibody, NCSTN antibody, nct antibody, ncstn antibody, CpipJ_CPIJ001617 antibody, Ncstn antibody, aph-2 antibody
    背景
    This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease, however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.,NCSTN,ATAG1874,nicastrin,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Notch Signaling Pathway,ESC Pluripotency and Differentiation,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Neurodegenerative Diseases Markers,Stem Cells,NCSTN
    分子量
    76kDa/78kDa
    基因ID
    23385
    UniProt
    Q92542
    途径
    Notch Signaling, Neurotrophin Signaling Pathway
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