This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.,UNC5B,UNC5H2,p53RDL1,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Neuroscience,Cardiovascular,UNC5B