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MAPK8/9/10 抗体

MAPK8/9/10 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7268630
发货至: 中国
  • 抗原 See all MAPK8/9/10 products
    MAPK8/9/10 (Mitogen-Activated Protein Kinase 8/9/10 (MAPK8/9/10))
    适用
    • 10
    • 9
    • 8
    宿主
    • 10
    • 1
    克隆类型
    • 10
    • 1
    多克隆
    标记
    • 11
    This MAPK8/9/10 antibody is un-conjugated
    应用范围
    • 10
    • 6
    • 6
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
    原理
    JNK1/2/3 Rabbit pAb
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein of human JNK1/2/3.
    亚型
    IgG
  • 应用备注
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    MAPK8/9/10 (Mitogen-Activated Protein Kinase 8/9/10 (MAPK8/9/10))
    别名
    MAPK8/MAPK9/MAPK10 (MAPK8/9/10 产品)
    背景
    JNK belongs to MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1,JNK2,and JNK3,MAPK8/MAPK9/MAPK10
    分子量
    35kDa/44kDa/48kDa/27kDa/52kDa
    基因ID
    5599, 5601, 5602
    UniProt
    P45983, P45984, P53779
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