METTL16 抗体 (AA 263-562)
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- 抗原 See all METTL16 抗体
- METTL16 (Methyltransferase Like 16 (METTL16))
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抗原表位
- AA 263-562
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This METTL16 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- 原理
- METTL16 Rabbit pAb
- 序列
- RIQGVPKVTY TEFCQGRTMR WALAWSFYDD VTVPSPPSKR RKLEKPRKPI TFVVLASVMK ELSLKASPLR SETAEGIVVV TTWIEKILTD LKVQHKRVPC GKEEVSLFLT AIENSWIHLR RKKRERVRQL REVPRAPEDV IQALEEKKPT PKESGNSQEL ARGPQERTPC GPALREGEAA AVEGPCPSQE SLSQEENPEP TEDERSEEKG GVEVLESCQG SSNGAQDQEA SEQFGSPVAE RGKRLPGVAG QYLFKCLINV KKEVDDALVE MHWVEGQNRD LMNQLCTYIR NQIFRLVAVN
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 263-562 of human METTL16 (NP_076991.3).
- 亚型
- IgG
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anti-Methyltransferase Like 16 (METTL16) antibody
METTL16 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3E8 unconjugated
anti-Methyltransferase Like 16 (METTL16) (N-Term) antibodyMETTL16 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔, 猴, Pig, 小鸡, Hamster, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Methyltransferase Like 16 (METTL16) (AA 38-87) antibodyMETTL16 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 猴, Pig, 小鸡, 非洲爪蟾, Hamster, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Methyltransferase Like 16 (METTL16) antibodyMETTL16 适用: 人 WB 宿主: 小鼠 Monoclonal 5F10 unconjugated
anti-Methyltransferase Like 16 (METTL16) (N-Term) antibodyMETTL16 适用: 人, 小鼠, 大鼠, 犬, Cow, 斑马鱼, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- METTL16 (Methyltransferase Like 16 (METTL16))
- 别名
- METTL16 (METTL16 产品)
- 别名
- fi09d09 antibody, im:7148386 antibody, mett10d antibody, wu:fi09d09 antibody, zgc:100981 antibody, zgc:158576 antibody, METT10D antibody, 2610100D03Rik antibody, 2810013M15Rik antibody, A830095F14Rik antibody, AI846133 antibody, Mett10d antibody, methyltransferase like 16 antibody, methyltransferase like 16 L homeolog antibody, mettl16 antibody, mettl16.L antibody, METTL16 antibody, Mettl16 antibody
- 背景
- RNA N6-methyltransferase that methylates adenosine residues at the N(6 position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs. In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA: specifically N6-methylates adenine in position 43 of U6 snRNAs. Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA or 7SL RNA. Specifically binds the 3'-end of the MALAT1 long non-coding RNA.,METTL16,METT10D,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,METTL16
- 分子量
- 25kDa/63kDa
- 基因ID
- 79066
- UniProt
- Q86W50
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