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MC1 Receptor 抗体

MC1R 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
产品编号 ABIN7268453
发货至: 中国
  • 抗原 See all MC1 Receptor (MC1R) 抗体
    MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
    适用
    • 62
    • 27
    • 11
    • 4
    • 3
    • 1
    • 1
    宿主
    • 64
    • 10
    克隆类型
    • 71
    • 3
    单克隆
    标记
    • 27
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    • 2
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
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    This MC1 Receptor antibody is un-conjugated
    应用范围
    • 50
    • 27
    • 26
    • 26
    • 14
    • 12
    • 8
    • 8
    • 6
    • 4
    • 2
    Western Blotting (WB)
    原理
    MC1 Receptor Rabbit mAb
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Monoclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    A synthesized peptide derived from human MC1 Receptor
    亚型
    IgG
    Top Product
    Discover our top product MC1R Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
    别名
    MC1R (MC1R 产品)
    背景
    This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008],CMM5, MSH-R, SHEP2,Endocrine & Metabolism,G protein signaling,G protein signaling_G-Protein-Coupled Receptors(GPCR),Neuroscience,Signal Transduction,MC1R
    分子量
    35kDa
    基因ID
    4157
    UniProt
    Q01726
    途径
    cAMP Metabolic Process, Feeding Behaviour
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