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MAML2 抗体 (AA 750-850)

MAML2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7268410
发货至: 中国
  • 抗原 See all MAML2 抗体
    MAML2 (Mastermind-Like 2 (MAML2))
    抗原表位
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 750-850
    适用
    • 26
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    宿主
    • 16
    • 11
    克隆类型
    • 16
    • 11
    多克隆
    标记
    • 17
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAML2 antibody is un-conjugated
    应用范围
    • 22
    • 12
    • 10
    • 9
    • 9
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    原理
    MAML2 Rabbit pAb
    序列
    NQQLMGKKQT LQRQIMEQKQ QLLLQQQMLA DAEKIAPQDQ INRHLSRPPP DYKDQRRNVG NMQPTAQYSG GSSTISLNSN QALANPVSTH TILTPNSSLL S
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    A synthetic peptide corresponding to a sequence within amino acids 750-850 of human MAML2 (NP_115803.1).
    亚型
    IgG
    Top Product
    Discover our top product MAML2 Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    MAML2 (Mastermind-Like 2 (MAML2))
    别名
    MAML2 (MAML2 产品)
    别名
    5930431H10 antibody, BC032967 antibody, MAM-3 antibody, MAM2 antibody, MAM3 antibody, MLL-MAML2 antibody, mastermind like 2 (Drosophila) antibody, mastermind-like transcriptional coactivator 2 antibody, mastermind like transcriptional coactivator 2 antibody, Maml2 antibody, MAML2 antibody
    背景
    The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed.,MAML2,MAM-3,MAM2,MAM3,MLL-MAML2,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Notch Signaling Pathway,Stem Cells,MAML2
    基因ID
    84441
    UniProt
    Q8IZL2
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