This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed.,LARS,HSPC192,ILFS1,LARS1,LEURS,LEUS,LFIS,LRS,PIG44,RNTLS,hr025Cl,Epigenetics & Nuclear Signaling,Endocrine & Metabolism,Mitochondrial metabolism,LARS