Lamin A/C 抗体
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- 抗原 See all Lamin A/C (LMNA) 抗体
- Lamin A/C (LMNA)
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适用
- 人
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This Lamin A/C antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- 原理
- [KO Validated] Lamin A/C Rabbit mAb
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Monoclonal Antibodies
- 纯化方法
- Affinity purification
- 质量等级
- KO Validated
- 免疫原
- Recombinant protein of human Lamin A/C.
- 亚型
- IgG
- Top Product
- Discover our top product LMNA Primary Antibody
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- 应用备注
- WB,1:50000 - 1:200000,IHC,1:50 - 1:1000,IF,1:50 - 1:1000,IP,1:50 - 1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- Lamin A/C (LMNA)
- 别名
- LMNA (LMNA 产品)
- 背景
- The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.,LMNA,CDCD1,CDDC,CMD1A,CMT2B1,EMD2,FPL,FPLD,FPLD2,HGPS,IDC,LDP1,LFP,LGMD1B,LMN1,LMNC,LMNL1,MADA,PRO1,lamin,Lamin A/C,Apoptosis,Cell Biology & Developmental Biology,Cell Cycle,Cytoskeleton,Cytoskeleton_Intermediate Filaments,Death Receptor Signaling Pathway,PI3K-Akt Signaling Pathway,Protein folding,Protein phosphorylation,Signal Transduction,Stem Cells,LMNA
- 分子量
- 62-74kDa
- 基因ID
- 4000
- UniProt
- P02545
- 途径
- Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
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