This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008],ISLET1, Isl-1,Cardiovascular,Cell Biology & Developmental Biology,Cell Type Marker,Cell Type Marker_Neuron marker,Endocrine & Metabolism,Endocrine and metabolic diseases,Endocrine and metabolic diseases_Diabetes,Epigenetics & Nuclear Signaling,Heart,Heart_Cardiogenesis,Neural Stem Cells,Neuroscience,Stem Cells,Transcription Factors,ISL1