IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008],IRAK-2,Cell Intrinsic Innate Immunity Signaling Pathway,Cytokines,Cytokines_Interleukins,Immunology & Inflammation,Innate Immunity_TLR Signaling,Kinase,Kinase_Serine/threonine kinases,Signal Transduction,Toll-like Receptor Signaling Pathway,IRAK2