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- 抗原 See all HCAR2 抗体
- HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
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抗原表位
- AA 250-350
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HCAR2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 原理
- HCAR2 Rabbit pAb
- 序列
- VRIRIFWLLH TSGTQNCEVY RSVDLAFFIT LSFTYMNSML DPVVYYFSSP SFPNFFSTLI NRCLQRKMTG EPDNNRSTSV ELTGDPNKTR GAPEALMANS G
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- A synthetic peptide corresponding to a sequence within amino acids 250-350 of human HCAR2 (NP_808219.1).
- 亚型
- IgG
- Top Product
- Discover our top product HCAR2 Primary Antibody
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anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) antibody
HCAR2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 200-228) antibodyHCAR2 适用: 人 WB 宿主: 兔 Polyclonal RB31358 unconjugated
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- 应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
- 别名
- HCAR2 (HCAR2 产品)
- 别名
- GPR109A antibody, HCA2 antibody, HM74a antibody, HM74b antibody, NIACR1 antibody, PUMAG antibody, Puma-g antibody, Gpr109a antibody, Gpr109b antibody, HM74 antibody, Hcar2 antibody, PUMA-G antibody, Pumag antibody, mHM74b antibody, HCAR2 antibody, HCAR3 antibody, hydroxycarboxylic acid receptor 2 antibody, HCAR2 antibody, Hcar2 antibody, LOC527744 antibody
- 背景
- Acts as a high affinity receptor for both nicotinic acid (also known as niacin and (D-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.,HCAR2,GPR109A,HCA2,HM74a,HM74b,NIACR1,PUMAG,Puma-g,Cancer,Tumor suppressors,p53 pathway,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Cell Biology & Developmental Biology,Apoptosis,Endocrine & Metabolism,Lipid Metabolism,Hydrolysis,Cardiovascular,Lipids,HCAR2
- 分子量
- 42kDa
- 基因ID
- 338442
- UniProt
- Q8TDS4
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