Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.,HTATIP2,CC3,SDR44U1,TIP30,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Immunology & Inflammation,Cardiovascular,Angiogenesis,HTATIP2