CHF1 antibody, GRIDLOCK antibody, GRL antibody, HERP1 antibody, HESR2 antibody, HRT2 antibody, bHLHb32 antibody, Herp1 antibody, Hrt2 antibody, hesr2 antibody, grl antibody, zgc:136746 antibody, hes related family bHLH transcription factor with YRPW motif 2 antibody, hairy/enhancer-of-split related with YRPW motif 2 antibody, hes-related family bHLH transcription factor with YRPW motif 2 antibody, HEY2 antibody, Hey2 antibody, hey2 antibody
背景
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.,HEY2,CHF1,GRIDLOCK,GRL,HERP1,HESR2,HRT2,bHLHb32,Epigenetics & Nuclear Signaling,Transcription Factors,Stem Cells,Cardiovascular,Heart,Cardiogenesis,HEY2