The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],ASH,EGFRBP-GRB2,Grb3-3,MST084,MSTP084,NCKAP2,GRB2,B Cell Receptor Signaling Pathway,Cancer,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Actins,Endocrine & Metabolism,Epigenetics & Nuclear Signaling,ErbB-HER Signaling Pathway,G protein signaling,G protein signaling_G-Protein-Coupled Receptors Signaling to MAPK/Erk,G protein signaling_Small G proteins,IL-6 Receptor Signaling Pathway,Immunology & Inflammation,Insulin Receptor Signaling Pathway,MAPK-Erk Signaling Pathway,MAPK-JNK Signaling Pathway,RNA Binding,Signal Transduction,T Cell Receptor Signaling Pathway,TGF-b-Smad Signaling Pathway,GRB2