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FEN1 抗体

FEN1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
产品编号 ABIN7267215
发货至: 中国
  • 抗原 See all FEN1 抗体
    FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))
    适用
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    宿主
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    克隆类型
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    单克隆
    标记
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    This FEN1 antibody is un-conjugated
    应用范围
    • 55
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    Western Blotting (WB), Immunohistochemistry (IHC)
    原理
    FEN-1 Rabbit mAb
    交叉反应
    人, 小鼠
    产品特性
    Monoclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    A synthesized peptide derived from human FEN-1
    亚型
    IgG
    Top Product
    Discover our top product FEN1 Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IHC,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))
    别名
    FEN1 (FEN1 产品)
    别名
    FEN-1 antibody, FEN1 antibody, AW538437 antibody, MF1 antibody, RAD2 antibody, cb879 antibody, fen-1 antibody, fen1 antibody, mf1 antibody, rad2 antibody, xFEN1a antibody, flap structure-specific endonuclease 1 antibody, flap endonuclease 1-like antibody, Flap endonuclease-1 antibody, 5'-3' exonuclease family protein antibody, flap structure specific endonuclease 1 antibody, flap structure-specific endonuclease 1 L homeolog antibody, nuclease, Rad2 family antibody, FEN1 antibody, LOC100808044 antibody, Bm1_49605 antibody, AT5G26680 antibody, Fen1 antibody, fen1 antibody, fen1.L antibody
    背景
    The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008],FEN-1, MF1, RAD2,DNA Damage & Repair,Epigenetics & Nuclear Signaling,FEN1
    分子量
    42kDa
    基因ID
    2237
    UniProt
    P39748
    途径
    Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
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