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FGL1 抗体

FGL1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
产品编号 ABIN7267179
发货至: 中国
  • 抗原 See all FGL1 抗体
    FGL1 (Fibrinogen-Like 1 (FGL1))
    适用
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    宿主
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    克隆类型
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    单克隆
    标记
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    This FGL1 antibody is un-conjugated
    应用范围
    • 46
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    Western Blotting (WB)
    原理
    FGL1 Rabbit mAb
    交叉反应
    产品特性
    Monoclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein of human FGL-1 Full length.
    亚型
    IgG
    Top Product
    Discover our top product FGL1 Primary Antibody
  • 应用备注
    WB,1:500 - 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.09 % sodium azide,50 % glycerol, pH 7.4.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    FGL1 (Fibrinogen-Like 1 (FGL1))
    别名
    FGL1 (FGL1 产品)
    别名
    MGC84748 antibody, FGL1 antibody, DKFZp470A2333 antibody, Frep1 antibody, Lfire1 antibody, HFREP1 antibody, HP-041 antibody, LFIRE-1 antibody, LFIRE1 antibody, Mfire1 antibody, fibrinogen like 1 L homeolog antibody, fibrinogen like 1 antibody, fibrinogen-like 1 antibody, fibrinogen-like protein 1 antibody, fgl1.L antibody, FGL1 antibody, Fgl1 antibody
    背景
    Fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. The FGL1-LAG-3 pathway maybe an important immune evasion mechanism and could contribute to current cancer immunotherapy efforts for several reasons. FGL1 inhibits antigen-specific T cell activation, and ablation of FGL1 in mice promotes T cell immunity. Blockade of the FGL1-LAG-3 interaction by monoclonal antibodies stimulates tumor immunity and is therapeutic against established mouse tumors in a receptor-ligand inter-dependent manner. FGL1 is highly produced by human cancer cells, and elevated FGL1 in the plasma of cancer patients is associated with a poor prognosis and resistance to anti-PD-1/B7-H1 therapy,FGL1,HFREP1,HP-041,LFIRE-1,LFIRE1,Cardiovascular,Blood,Coagulation,Serum Proteins,FGL1
    分子量
    36kDa
    基因ID
    2267
    UniProt
    Q08830
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