This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013],H-PAST, HPAST1, PAST, PAST1,Calcium Signaling,Cancer,Cardiovascular,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Lipid Metabolism,Lipid Metabolism_Cholesterol Metabolism,Lipids,Neuroscience,Signal Transduction,EHD1