This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],DFNA1, DIA1, DRF1, LFHL1, SCBMS, hDIA1,Cell Adhesion,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Actins,Cytoskeleton_Microfilaments,Cytoskeleton_Microtubules,Epigenetics & Nuclear Signaling,RNA Binding,Signal Transduction,TGF-b-Smad Signaling Pathway,DIAPH1