This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016],CDHF5, HDGC,Cancer,Cardiovascular,Cell Adhesion,Cell Adhesion_Cadherins,Cell Biology & Developmental Biology,Cytoskeleton,Heart,Heart_Cardiac arrhythmias,Invasion and Metastasis,Signal Transduction,DSG2