COX11P antibody, im:6904550 antibody, zgc:162286 antibody, 2010004I09Rik antibody, COX11 antibody, COX11, cytochrome c oxidase copper chaperone antibody, cytochrome c oxidase assembly homolog 11 (yeast) antibody, cytochrome c oxidase assembly protein 11 antibody, COX11 cytochrome c oxidase assembly homolog (yeast) antibody, cytochrome c oxidase assembly protein antibody, COX11, cytochrome c oxidase copper chaperone pseudogene 1 antibody, COX11 cytochrome c oxidase copper chaperone antibody, COX11 antibody, cox11 antibody, Cox11 antibody, COX11P1 antibody
背景
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6.,COX11,COX11P,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,COX11