This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.,CCDC88A,APE,GIRDIN,GIV,GRDN,HkRP1,KIAA1212,PEHO,girdin,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Microtubules,Neuroscience,CCDC88A