Chromosome 7 Open Reading Frame 20 (C7orf20) (AA 1-327) 抗体
C7orf20
适用: 人
WB
宿主: 兔
Polyclonal
unconjugated
1 image
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- 抗原 See all Chromosome 7 Open Reading Frame 20 (C7orf20) 抗体
- Chromosome 7 Open Reading Frame 20 (C7orf20)
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抗原表位
- AA 1-327
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB)
- 原理
- GET4 Rabbit pAb
- 序列
- MAAAAAMAEQ ESARNGGRNR GGVQRVEGKL RASVEKGDYY EAHQMYRTLF FRYMSQSKHT EARELMYSGA LLFFSHGQQN SAADLSMLVL ESLEKAEVEV ADELLENLAK VFSLMDPNSP ERVTFVSRAL KWSSGGSGKL GHPRLHQLLA LTLWKEQNYC ESRYHFLHSA DGEGCANMLV EYSTSRGFRS EVDMFVAQAV LQFLCLKNKS SASVVFTTYT QKHPSIEDGP PFVEPLLNFI WFLLLAVDGG KLTVFTVLCE QYQPSLRRDP MYNEYLDRIG QLFFGVPPKQ TSSYGGLLGN LLTSLMGSSE QEDGEESPSD GSPIELD
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-327 of human GET4 (NP_057033.2).
- 亚型
- IgG
- Top Product
- Discover our top product C7orf20 Primary Antibody
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anti-Chromosome 7 Open Reading Frame 20 (C7orf20) (AA 32-81) antibody
C7orf20 适用: 人, Cow, 马, 斑马鱼, Pig WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB,1:500 - 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- Chromosome 7 Open Reading Frame 20 (C7orf20)
- 别名
- GET4 (C7orf20 产品)
- 别名
- cee antibody, cgi-20 antibody, c7orf20 antibody, get4 antibody, C7orf20 antibody, CEE antibody, TRC35 antibody, 1110007L15Rik antibody, AW412535 antibody, Cee antibody, RGD1311660 antibody, C25H7ORF20 antibody, get4-a antibody, golgi to ER traffic protein 4 antibody, chromosome 7 open reading frame 20 antibody, Cee antibody, golgi to ER traffic protein 4 homolog (S. cerevisiae) antibody, golgi to ER traffic protein 4 S homeolog antibody, get4 antibody, Bm1_33940 antibody, LOC100136505 antibody, GET4 antibody, Get4 antibody, get4.S antibody
- 背景
- As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD, a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.,GET4,C7orf20,CEE,CGI-20,TRC35,Cell Biology & Developmental Biology,GET4
- 分子量
- 30kDa/36kDa
- 基因ID
- 51608
- UniProt
- Q7L5D6
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