Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration.,CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975,Cell Biology & Developmental Biology,Hedgehog Signaling Pathway,Kinase,Kinase_Serine/threonine kinases,Signal Transduction,Stem Cells,Wnt/β-Catenin Signaling Pathway,CSNK1A1