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- 抗原 See all BAZ2A 抗体
- BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This BAZ2A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
- 原理
- BAZ2A Rabbit pAb
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein of Human BAZ2A.
- 亚型
- IgG
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anti-Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A) (N-Term) antibody
BAZ2A 适用: 人 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A) (AA 97-266) antibodyBAZ2A 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A) (AA 1-1905) antibodyBAZ2A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A) (N-Term) antibodyBAZ2A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A) antibodyBAZ2A 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))
- 别名
- BAZ2A (BAZ2A 产品)
- 背景
- Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. Directly stimulates the ATPase activity of SMARCA5 in the NoRC-5 ISWI chromatin remodeling complex. The NoRC-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NoRC-5 ISWI chromatin remodeling complex. Within the NoRC-5 ISWI chromatin remodeling complex, mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing (By similarity. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription (By similarity. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac, leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac (By similarity. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity.,TIP5,WALp3,BAZ2A / TIP5,BAZ2A,Epigenetics & Nuclear Signaling,BAZ2A
- 基因ID
- 11176
- UniProt
- Q9UIF9
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