cb1023 antibody, baiap2l1 antibody, zgc:85624 antibody, RGD1308452 antibody, BAIAP2L1 antibody, MGC131079 antibody, 1300006M19Rik antibody, AI585895 antibody, IRTKS antibody, zgc:110192 antibody, BAI1-associated protein 2-like 1a antibody, BAI1-associated protein 2-like 1 antibody, BAI1 associated protein 2 like 1 antibody, BAI1 associated protein 2 like 1 L homeolog antibody, BAI1-associated protein 2-like 1b antibody, baiap2l1a antibody, Baiap2l1 antibody, BAIAP2L1 antibody, baiap2l1.L antibody, baiap2l1b antibody
背景
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.,BAIAP2L1,IRTKS,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,BAIAP2L1