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ATR 抗体 (pThr1989)

ATR 适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7265777
发货至: 中国
  • 抗原 See all ATR 抗体
    ATR (ATR serine/threonine kinase (ATR))
    抗原表位
    • 11
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr1989
    适用
    • 45
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 39
    • 5
    • 2
    克隆类型
    • 42
    • 4
    多克隆
    标记
    • 30
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATR antibody is un-conjugated
    应用范围
    • 27
    • 20
    • 19
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    原理
    Phospho-ATR-T1989 Rabbit pAb
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Phosphorylated Antibodies
    纯化方法
    Affinity purification
    免疫原
    A phospho synthetic peptide corresponding to residues surrounding T1989 of Human ATR.
    亚型
    IgG
  • 应用备注
    WB,1:500 - 1:2000,IHC,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    ATR (ATR serine/threonine kinase (ATR))
    别名
    ATR (ATR 产品)
    别名
    FCTCS antibody, FRP1 antibody, MEC1 antibody, SCKL antibody, SCKL1 antibody, ATR serine/threonine kinase antibody, ataxia telangiectasia and Rad3 related antibody, ATR antibody, Atr antibody
    背景
    The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.,ATR,FCTCS,FRP1,MEC1,SCKL,SCKL1,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Phosphorylation,DNA Damage & Repair,Cancer,Tumor suppressors,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Cell Cycle,G1/S Checkpoint,G2/M DNA Damage Checkpoint,Protein phosphorylation,ATR
    分子量
    294kDa/297kDa/301kDa
    基因ID
    545
    UniProt
    Q13535
    途径
    Positive Regulation of Response to DNA Damage Stimulus
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