This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008],14-3-3, 1C5, HS1,Apoptosis,Apoptosis_Mitochondrial Control of Apoptosis,Cell Biology & Developmental Biology,Cell Cycle,Cell Type Marker,Cell Type Marker_Neuron marker,Cell Type Marker_Synapse marker,Epigenetics & Nuclear Signaling,G2/M DNA Damage Checkpoint,Hippo Signaling Pathway,MAPK-Erk Signaling Pathway,MAPK-JNK Signaling Pathway,Neuroscience,PI3K-Akt Signaling Pathway,Signal Transduction,Stem Cells,YWHAQ