MICU1 抗体
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- 抗原 See all MICU1 抗体
- MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))
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适用
- 人, 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MICU1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- 原理
- MICU1 Monoclonal Antibody
- 特异性
- The antibody detects endogenous MICU1 protein.
- 纯化方法
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen
- 免疫原
- Recombinant Protein
- 亚型
- IgG1
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anti-Mitochondrial Calcium Uptake 1 (MICU1) antibody
MICU1 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF 宿主: 小鼠 Monoclonal 4E7 unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) antibodyMICU1 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) (AA 55-191) antibodyMICU1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) antibodyMICU1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) (AA 113-126) antibodyVerified MICU1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) (AA 445-474), (C-Term) antibodyMICU1 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial Calcium Uptake 1 (MICU1) (AA 380-478) antibodyMICU1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:1000-1:2000), IF (1:100-1:200), IHC-P (1:100-1:200).
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- 抗原
- MICU1 (Mitochondrial Calcium Uptake 1 (MICU1))
- 别名
- MICU1 (MICU1 产品)
- 别名
- CALC antibody, CBARA1 antibody, EFHA3 antibody, C730016L05Rik antibody, Calc antibody, Cbara1 antibody, mitochondrial calcium uptake 1 antibody, MICU1 antibody, Micu1 antibody
- 背景
- Mouse Anti-MICU1 Monoclonal Antibody,Most PKMT substrates are histone proteins and transcription factors, emphasizing the importance of lysine methylation in regulating chromatin structure and gene expression. Lys9 of histone H3 is mono- or di-methylated by G9A/GLP and tri-methylated by SETDB1 to activate transcription. JHDM3A-mediated demethylation of the same residue creates mono-methyl Lys9 and inhibits gene transcription . Tumor suppressor p53 is regulated by methylation of at least four sites. p53-mediated transcription is repressed following mono-methylation of p53 at Lys370 by SMYD2, di-methylation at the same residue further inhibits p53 by preventing association with 53BP1. Concomitant di-methylation at Lys382 inhibits p53 ubiquitination following DNA damage. Mono-methylation at Lys382 by SET8 suppresses p53 transcriptional activity, while SET7/9 mono-methylation at Lys372 inhibits SMYD2 methylation at Lys370 and stabilizes the p53 protein. Di-methylation at Lys373 by G9A/GLP inhibits p53-mediated apoptosis and correlates with tri-methylation of histone H3 Lys9 at the p21 promoter . Overexpression of PKMTs is associated with multiple forms of human cancer, which has generated tremendous interest in targeting protein lysine methyltransferases in drug discovery research.,Calcium uptake protein 1, mitochondrial
- 基因ID
- 10367
- UniProt
- Q9BPX6
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