SH3KBP1 抗体 (AA 591-665)
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- 抗原 See all SH3KBP1 抗体
- SH3KBP1 (SH3-Domain Kinase Binding Protein 1 (SH3KBP1))
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抗原表位
- AA 591-665
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SH3KBP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 预测反应
- Human,Mouse,Rat,Cow,Sheep,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human SH3KBP1
- 亚型
- IgG
- Top Product
- Discover our top product SH3KBP1 Primary Antibody
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anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) antibody
SH3KBP1 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) (AA 1-665) antibodySH3KBP1 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) (AA 224-308) antibodySH3KBP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F11 unconjugated
anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) (N-Term) antibodySH3KBP1 适用: 人, 大鼠, 小鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) antibodySH3KBP1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) (AA 107-156) antibodySH3KBP1 适用: 人, 大鼠, 小鼠, 兔, 犬, 豚鼠, Cow, 马, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) (N-Term) antibodySH3KBP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SH3-Domain Kinase Binding Protein 1 (SH3KBP1) (N-Term) antibodySH3KBP1 适用: 人, 大鼠, 小鼠, 兔, 犬, 豚鼠, Cow, 马, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- SH3KBP1 (SH3-Domain Kinase Binding Protein 1 (SH3KBP1))
- 别名
- Sh3kbp1 (SH3KBP1 产品)
- 别名
- CD2BP3 antibody, CIN85 antibody, GIG10 antibody, HSB-1 antibody, HSB1 antibody, MIG18 antibody, 1200007H22Rik antibody, 1700125L08Rik antibody, 5830464D22Rik antibody, AI447724 antibody, IN85 antibody, Ruk antibody, Seta antibody, SH3 domain containing kinase binding protein 1 antibody, SH3-domain kinase binding protein 1 antibody, SH3 domain-containing kinase-binding protein 1 antibody, SH3KBP1 antibody, sh3kbp1 antibody, LOC100551401 antibody, Sh3kbp1 antibody
- 背景
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Synonyms: Cbl interacting protein, Cbl interacting protein of 85 kDa, CD2 binding protein 3, CD2BP3, CIN 85, CIN85, GIG 10, GIG10, HSB 1, Human Src family kinase binding protein 1, MIG 18, MIG18, Migration inducing gene 18 protein, SH3 domain kinase binding protein 1, SH3BP 1, Src family kinase binding protein 1, src related kinase binding protein 1, SH3K1_HUMAN.
Background: SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.
- 基因ID
- 30011
- 途径
- EGFR Signaling Pathway, EGFR Downregulation
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