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Recombinant PDCD1 (Pembrolizumab Biosimilar) 抗体

适用: 人 FACS, in vivo 宿主: 小鼠 Monoclonal unconjugated Recombinant Antibody
产品编号 ABIN7200668
发货至: 中国
  • 抗原 See all PDCD1 (Pembrolizumab Biosimilar) products
    PDCD1 (Pembrolizumab Biosimilar)
    抗体类型
    Recombinant Antibody
    适用
    宿主
    • 1
    • 1
    小鼠
    克隆类型
    • 2
    单克隆
    标记
    • 2
    This PDCD1 (Pembrolizumab Biosimilar) antibody is un-conjugated
    应用范围
    Flow Cytometry (FACS), In vivo Studies (in vivo)
    原理
    Pembrolizumab Biosimilar, Human PD-1 Monoclonal Antibody
    特异性
    The in vivo grade pembrolizumab biosimilar specifically binds to the programmed cell death protein 1 (PD-1 or PD1), antagonizing its interaction with its known ligands PD-L1 or PDL1, and PD-L2 or PDL2.
    产品特性
    Recombinant Humanized IgG4 Monoclonal Antibody.
    纯化方法
    Protein A affinity column
    纯度
    > 95% by SDS-PAGE under reducing conditions and HPLC.
    过滤
    0.2 μm filtered
    内毒素水平
    < 1 EU per 1 mg of the protein by the LAL method.
    免疫原
    The anti-human programmed cell death protein 1 (PD-1) monoclonal antibody pembrolizumab biosimilar was produced in the pembrolizumab biosimilar CHO stable cell line.
    亚型
    IgG4 kappa
  • 应用备注
    ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by pembrolizumab.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS, pH 7.4, no stabilizers or preservatives.
    储存液
    Without preservative
    注意事项
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
    有效期
    12 months
  • 抗原
    PDCD1 (Pembrolizumab Biosimilar)
    Abstract
    PDCD1 (Pembrolizumab Biosimilar) 产品
    物质类
    Biosimilar
    背景
    What is Pembrolizumab biosimilar research grade? Pembrolizumab is a highly selective IgG4-kappa humanized monoclonal antibody against PD-1 receptor. It was generated by grafting the variable sequences of a very high-affinity mouse antihuman PD-1 antibody onto a human IgG4-kappa isotype with the containing a stabilizing S228P Fc mutation. It contains 32 cysteine residues and the complete folded molecule includes 4 disulfide linkages as interchain bonds and 23 interchain bonds. Pembrolizumab Biosimilar uses the same protein sequences as the therapeutic antibody pembrolizumab.
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