Recombinant ErbB2/Her2 (Pertuzumab Biosimilar) 抗体
适用: 人
FACS, in vivo
宿主: 小鼠
Monoclonal
unconjugated
Recombinant Antibody
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- 抗原 See all ErbB2/Her2 (Pertuzumab Biosimilar) products
- ErbB2/Her2 (Pertuzumab Biosimilar)
- 抗体类型
- Recombinant Antibody
- 适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This ErbB2/Her2 (Pertuzumab Biosimilar) antibody is un-conjugated
- 应用范围
- Flow Cytometry (FACS), In vivo Studies (in vivo)
- 原理
- Pertuzumab Biosimilar, Human HER2 Monoclonal Antibody
- 特异性
- The monoclonal antibody pertuzumab biosimilar specifically binds to the human HER2/ErbB-2/c-neu.
- 产品特性
- Recombinant humanized IgG1 Monoclonal Antibody.
- 纯化方法
- Protein A affinity column
- 纯度
- > 95% by SDS-PAGE under reducing conditions and HPLC.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- < 1 EU per 1 mg of the protein by the LAL method.
- 免疫原
- The monoclonal antibody pertuzumab biosimilar was produced in the pertuzumab biosimilar CHO stable cell line.
- 亚型
- IgG1 kappa
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- 应用备注
- ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by pertuzumab.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS, pH 7.4, no stabilizers or preservatives.
- 储存液
- Without preservative
- 注意事项
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
- 有效期
- 12 months
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- 抗原
- ErbB2/Her2 (Pertuzumab Biosimilar)
- Abstract
- ErbB2/Her2 (Pertuzumab Biosimilar) 产品
- 物质类
- Biosimilar
- 背景
- Pertuzumab, a humanized monoclonal antibody, inhibits HER dimerization and is used for the treatment of HER2-positive metastatic breast cancer, in combination with trastuzumab and docetaxel. By binding to HER2, Pertuzumab inhibits the dimerization of HER2 with other HER receptors, resulting in slowed tumor growth.
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