MUC16 抗体 (AA 1-200)
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- 抗原 See all MUC16 (CA125) 抗体
- MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))
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抗原表位
- AA 1-200
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MUC16 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
- 原理
- MUC16 Antibody
- 纯化方法
- Purified antibody
- 免疫原
- Purified recombinant fragment of human MUC16 (AA: 1-200) expressed in E. Coli.
- 克隆位点
- 4C8C8
- 亚型
- IgG1
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- 应用备注
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ELISA: 1/10000
FCM: 1/200-1/400
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- 抗原
- MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))
- 别名
- MUC16 (CA125 产品)
- 别名
- CA125 antibody, 1110008I14Rik antibody, Ca125 antibody, Gm1480 antibody, RGD1308422 antibody, MUC16 antibody, mucin 16, cell surface associated antibody, mucin 16 antibody, mucin-16 antibody, MUC16 antibody, Muc16 antibody, LOC476718 antibody, LOC712735 antibody
- 背景
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Description:
This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes.
Aliases: CA125
- 分子量
- 1519kDa
- 基因ID
- 94025
- UniProt
- Q8WXI7
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