ERCC1 抗体 (AA 1-120)
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- 抗原 See all ERCC1 抗体
- ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))
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抗原表位
- AA 1-120
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This ERCC1 antibody is un-conjugated
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应用范围
- ELISA, Flow Cytometry (FACS)
- 原理
- ERCC1 Antibody
- 纯化方法
- Purified antibody
- 免疫原
- Purified recombinant fragment of human ERCC1 (AA: 1-120) expressed in E. Coli.
- 克隆位点
- 3F9E9
- 亚型
- IgG1
- Top Product
- Discover our top product ERCC1 Primary Antibody
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- 应用备注
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ELISA: 1/10000
FCM: 1/200-1/400
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- 抗原
- ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))
- 别名
- ERCC1 (ERCC1 产品)
- 别名
- COFS4 antibody, RAD10 antibody, UV20 antibody, Ercc-1 antibody, ercc1 antibody, T12H1.18 antibody, T12H1_18 antibody, UV REPAIR DEFICIENT 7 antibody, UVR7 antibody, ERCC excision repair 1, endonuclease non-catalytic subunit antibody, excision repair cross-complementing rodent repair deficiency, complementation group 1 antibody, DNA excision repair protein ERCC-1 antibody, nucleotide repair protein antibody, excision repair cross-complementation group 1 L homeolog antibody, excision repair cross-complementation group 1 antibody, ERCC1 antibody, Ercc1 antibody, CC1G_04546 antibody, CpipJ_CPIJ013903 antibody, PITG_13719 antibody, ercc1 antibody, ercc1.L antibody
- 背景
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Description:
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
Aliases: UV20, COFS4, RAD10
- 分子量
- 32.6kDa
- 基因ID
- 2067
- UniProt
- P07992
- 途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
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