FADD 抗体 (AA 20-150)
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- 抗原 See all FADD 抗体
- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
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抗原表位
- AA 20-150
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This FADD antibody is un-conjugated
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应用范围
- ELISA, Flow Cytometry (FACS)
- 原理
- FADD Antibody
- 纯化方法
- Purified antibody
- 免疫原
- Purified recombinant fragment of human FADD (AA: 20-150) expressed in E. Coli.
- 克隆位点
- 5A6A2
- 亚型
- IgG1
- Top Product
- Discover our top product FADD Primary Antibody
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- 应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- 抗原
- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
- 别名
- FADD (FADD 产品)
- 别名
- MORT1 antibody, Mort1/FADD antibody, Mort1 antibody, TNFRSF6 antibody, adaptor antibody, fadd antibody, mort1 antibody, xfadd antibody, Fas associated via death domain antibody, Fas (TNFRSF6)-associated via death domain antibody, Fas associated via death domain S homeolog antibody, Fas (tnfrsf6)-associated via death domain antibody, FADD antibody, Fadd antibody, fadd.S antibody, fadd antibody
- 背景
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Description:
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Aliases: GIG3, MORT1
- 分子量
- 23.3kDa
- 基因ID
- 8772
- UniProt
- Q13158
- 途径
- Apoptosis, TLR signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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