SETD7 抗体 (AA 107-366)
-
- 抗原 See all SETD7 抗体
- SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
-
抗原表位
- AA 107-366
-
适用
- 人, 大鼠, 猴
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This SETD7 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Neutralization (Neut)
- 纯化方法
- purified
- 免疫原
- Purified recombinant fragment of human SETD7 (AA: 107-366) expressed in E. coli.
- 克隆位点
- 3D6G11
- 亚型
- IgG1
- Top Product
- Discover our top product SETD7 Primary Antibody
-
-
- 应用备注
- ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: N/A, ICC: N/A, IHC: 1:200 - 1:1000
- 限制
- 仅限研究用
-
- 缓冲液
- Purified antibody in PBS with 0.05 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- 4°C, -20°C for long term storage
-
- 抗原
- SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
- 别名
- SETD7 (SETD7 产品)
- 别名
- KMT7 antibody, SET7 antibody, SET7/9 antibody, SET9 antibody, set7 antibody, zgc:101860 antibody, zgc:92330 antibody, 1600028F23Rik antibody, H3K4MT antibody, Set7 antibody, Set7/9 antibody, mKIAA1717 antibody, SET domain containing lysine methyltransferase 7 antibody, SET domain containing (lysine methyltransferase) 7 antibody, SETD7 antibody, setd7 antibody, Setd7 antibody
- 背景
-
Description: Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates Lys-189 of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Aliases: KMT7, SET7, SET9, SET7/9
- 分子量
- 40.7 kDa
- 基因ID
- 80854
-