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CXCR2 抗体

CXCR2 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 7E9H12 unconjugated
产品编号 ABIN7193273
发货至: 中国
  • 抗原 See all CXCR2 抗体
    CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))
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    宿主
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    小鼠
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    单克隆
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    This CXCR2 antibody is un-conjugated
    应用范围
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    ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
    原理
    CD182 Antibody
    纯化方法
    Purified antibody
    免疫原
    Purified recombinant fragment of human CD182 expressed in E. Coli.
    克隆位点
    7E9H12
    亚型
    IgG1
    Top Product
    Discover our top product CXCR2 Primary Antibody
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified antibody in PBS with 0.05 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • 抗原
    CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))
    别名
    CD182 (CXCR2 产品)
    别名
    CD182 antibody, CDw128b antibody, CMKAR2 antibody, IL8R2 antibody, IL8RA antibody, IL8RB antibody, CXC-R2 antibody, CXCR-2 antibody, CD128 antibody, CDw128 antibody, Cmkar2 antibody, Gpcr16 antibody, IL-8Rh antibody, IL-8rb antibody, Il8rb antibody, mIL-8RH antibody, C-X-C motif chemokine receptor 2 antibody, chemokine (C-X-C motif) receptor 2 antibody, Cxcr2 antibody, CXCR2 antibody
    背景

    Description:

    The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

    Aliases: CXCR2, IL8R2, IL8RA, IL8RB, CMKAR2, CDw128b

    分子量
    40.8kDa
    基因ID
    3579
    UniProt
    P25025
    途径
    cAMP Metabolic Process
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