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- 抗原 See all NCBP1 抗体
- NCBP1 (Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NCBP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized peptide derived from N-terminal of Human NCBP1.
- 亚型
- IgG
- Top Product
- Discover our top product NCBP1 Primary Antibody
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anti-Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1) (AA 1-790) antibody
NCBP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1) (N-Term) antibodyNCBP1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1) (AA 647-675), (C-Term) antibodyNCBP1 适用: 人 WB 宿主: 兔 Polyclonal RB41850 unconjugated
anti-Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1) (AA 2-99) antibodyNCBP1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1E9 unconjugated
anti-Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1) (N-Term) antibodyNCBP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1) (N-Term) antibodyNCBP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1) (AA 2-100) antibodyNCBP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E9 unconjugated
anti-Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1) (N-Term) antibodyNCBP1 适用: 人, Cow, 兔, 犬, Pig, 非洲爪蟾, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB:1:500-1:3000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- NCBP1 (Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1))
- 别名
- NCBP1 (NCBP1 产品)
- 别名
- CBP80 antibody, CG7035 antibody, Dmel\\CG7035 antibody, EG:84H4.3 antibody, ncbp antibody, sto1 antibody, cbp80 antibody, AU014645 antibody, AW538051 antibody, NCBP antibody, Sto1 antibody, ncbp1 antibody, ABA HYPERSENSITIVE 1 antibody, ATCBP80 antibody, CAP-BINDING PROTEIN 80 antibody, ENS antibody, ENSALADA antibody, NUCLEAR CAP-BINDING PROTEIN CBP80 antibody, T10F5.8 antibody, T10F5_8 antibody, cap binding protein 80 antibody, nuclear cap binding protein subunit 1 antibody, nuclear cap binding protein subunit 1 S homeolog antibody, nuclear cap binding protein subunit 1, 80kDa antibody, nuclear cap binding protein subunit 1 L homeolog antibody, ARM repeat superfamily protein antibody, Nuclear cap-binding protein subunit 1-A antibody, Nuclear cap-binding protein subunit 1 antibody, Cbp80 antibody, ncbp1 antibody, ncbp1.S antibody, NCBP1 antibody, Ncbp1 antibody, ncbp1.L antibody, ABH1 antibody, nbp1a antibody, ncbp-1 antibody
- 背景
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Background: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure.
Izaurralde E., Cell 78:657-668(1994).
Kataoka N., Nucleic Acids Res. 22:3861-3865(1994).
Humphray S.J., Nature 429:369-374(2004).Aliases: 80 kDa nuclear cap-binding protein antibody, CBP80 antibody, MGC2087 antibody, NCBP 80 kDa subunit antibody, NCBP antibody, ncbp1 antibody, NCBP1_HUMAN antibody, nuclear cap binding protein subunit 1 antibody, nuclear cap binding protein subunit 1, 80 kDa antibody, Nuclear cap-binding protein subunit 1 antibody, Sto1 antibody
- UniProt
- Q09161
- 途径
- Ribonucleoprotein Complex Subunit Organization, Photoperiodism, Methionine Biosynthetic Process
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