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- 抗原 See all MERTK 抗体
- MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MERTK antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized peptide derived from N-terminal of Human MERTK.
- 亚型
- IgG
- Top Product
- Discover our top product MERTK Primary Antibody
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anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 587-858) antibody
MERTK 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 501-600) antibodyMERTK 适用: 小鼠 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibodyMERTK 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 55-148) antibodyMERTK 适用: 人 IHC, IHC (f) 宿主: 小鼠 Monoclonal MERTK-3015 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 402-416), (Extracellular), (N-Term) antibodyMERTK 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 840-999) antibodyMERTK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-120) antibodyMERTK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D2 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibodyMERTK 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB17701 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 946-980), (C-Term) antibodyMERTK 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB50416 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (Extracellular Domain) antibodyMERTK 适用: 人 WB 宿主: 小鼠 Monoclonal A311F9G3 unconjugated
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- 应用备注
- WB:1:500-1:3000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
- 别名
- MERTK (MERTK 产品)
- 别名
- MER antibody, RP38 antibody, c-mer antibody, Eyk antibody, Mer antibody, Nyk antibody, nmf12 antibody, rdy antibody, C-EYK antibody, MERTK antibody, DKFZp469D2215 antibody, si:ch1073-268l12.2 antibody, MER proto-oncogene, tyrosine kinase antibody, c-mer proto-oncogene tyrosine kinase antibody, c-mer proto-oncogene tyrosine kinase a antibody, MERTK antibody, Mertk antibody, mertka antibody
- 背景
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Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Graham D.K., Cell Growth Differ. 5:647-657(1994).
Gal A., Nat. Genet. 26:270-271(2000).
Hillier L.W., Nature 434:724-731(2005).Aliases: c MER antibody, c mer proto oncogene tyrosine kinase antibody, c-mer antibody, cMER antibody, cmer protooncogene tyrosine kinase antibody, Eyk antibody, MER antibody, MER receptor tyrosine kinase antibody, MERK antibody, MERPEN antibody, Mertk antibody, MERTK c-mer proto-oncogene tyrosine kinase antibody, MERTK_HUMAN antibody, MGC133349 antibody, nmf12 antibody, Nyk antibody, Proto oncogene tyrosine protein kinase MER antibody, Proto oncogene tyrosine protein kinase MER precursor antibody, Proto-oncogene c-Mer antibody, Receptor tyrosine kinase MerTK antibody, RP38 antibody, STK kinase antibody, Tyrosine-protein kinase Mer antibody
- UniProt
- Q12866
- 途径
- RTK signaling
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