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- 抗原 See all MARK2 抗体
- MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MARK2 antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized peptide derived from N-terminal of Human MARK2.
- 亚型
- IgG
- Top Product
- Discover our top product MARK2 Primary Antibody
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anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 401-500) antibody
MARK2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 3B12 unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 600-630) antibodyMARK2 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (Internal Region) antibodyMARK2 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 600-630), (C-Term) antibodyMARK2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2527-2528 unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 373-594) antibodyMARK2 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) antibodyMARK2 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 1-755) antibodyMARK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 401-500) antibodyMARK2 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 3C5 unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (Isoform A), (pThr595) antibodyMARK2 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (N-Term) antibodyMARK2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB:1:500-1:3000, IF:1:100-1:500,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))
- 别名
- MARK2 (MARK2 产品)
- 别名
- EMK-1 antibody, EMK1 antibody, PAR-1 antibody, Par-1b antibody, Par1b antibody, AU024026 antibody, Emk antibody, Par-1 antibody, mKIAA4207 antibody, microtubule affinity regulating kinase 2 antibody, MAP/microtubule affinity regulating kinase 2 antibody, MARK2 antibody, Mark2 antibody
- 背景
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Background: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
Espinosa L., Cytogenet. Cell Genet. 81:278-282(1998).
Lizcano J.M., EMBO J. 23:833-843(2004).
Taylor T.D., Nature 440:497-500(2006).Aliases: ELKL motif kinase 1 antibody, ELKL motif kinase antibody, EMK-1 antibody, EMK1 antibody, MAP/microtubule affinity regulating kinase 2 antibody, MAP/microtubule affinity-regulating kinase 2 antibody, Mark2 antibody, MARK2_HUMAN antibody, MGC99619 antibody, PAR 1 antibody, Par 1b antibody, PAR1 homolog antibody, Par1b antibody, Ser/Thr protein kinase PAR 1B antibody, Serine/threonine protein kinase EMK antibody, Serine/threonine protein kinase MARK2 antibody, Serine/threonine-protein kinase MARK2 antibody
- UniProt
- Q7KZI7
- 途径
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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